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1

Efficient Functionalization of 2‘,5‘-Oligoadenylates with Sulfur

Lesiak, Krystyna, Torrence, Paul F.

Journal:

Bioconjugate Chemistry

Year:

1997

Language:

english

File:

PDF, 139 KB

english, 1997

2

Synthesis of a Novel C-Nucleoside, 2-Amino-7-(2-deoxy-β- D- erythro -pentofuranosyl)-3H,5H-pyrrolo-[3,2-d]pyrimidin-4-one (2′-Deoxy-9-deazaguanosine)

Gibson, Eric S., Lesiak, Krystyna, Watanabe, Kyoichi A., Gudas, Lorraine J., Pankiewicz, Krzysztof W.

Journal:

Nucleosides and Nucleotides

Year:

1999

Language:

english

File:

PDF, 788 KB

english, 1999

3

ChemInform Abstract: Synthesis of a Novel C-Nucleoside, 2-Amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-3H,5H-pyrrolo [3,2-d]pyrimidin-4-one (2′-Deoxy-9-deazaguanosine) (IX).

Eric S. Gibson, Krystyna Lesiak, Kyoichi A. Watanabe, Lorraine J. Gudas, Krzysztof W. Pankiewicz

Journal:

Year:

1999

File:

PDF, 34 KB

1999

4

ChemInform Abstract: Novel Mycophenolic Adenine Bis(phosphonate)s as Potent Anticancer Agents and Inducers of Cells Differentiation.

Krzysztof W. Pankiewicz, Krystyna Lesiak-Watanabe

Journal:

Year:

1999

File:

PDF, 26 KB

1999

5

Photochemical crosslinking in oligonucleotide-protein complexes between a bromine-substituted 2-5A analog and 2-5A-dependent RNase by ultraviolet lamp or laser

Nancy L. Nolan-Sorden, Krystyna Lesiak, Bernard Bayard, Paul F. Torrence, Robert H. Silverman

Journal:

Analytical Biochemistry

Year:

1990

Language:

english

File:

PDF, 1.23 MB

english, 1990

6

Aliphatic and Alicyclic Diols Induce Melanogenesis in Cultured Cells and Guinea Pig Skin

Brown, David A, Ren, Wu-Yun, Khorlin, Alexander, Lesiak, Krystyna, Conklin, Dorothy, Watanabe, Kyoichi A, Seidman, Michael M, George, Jay

Journal:

The Journal of Investigative Dermatology

Year:

1998

Language:

english

File:

PDF, 968 KB

english, 1998

7

The solid-phase synthesis of 2-5-linked oligoriboadenylates containing 8-bromoadenine

Krystyna B. Lesiak, Bogdan Uznanski, Paul F. Torrence

Journal:

Applied Biochemistry and Biotechnology

Year:

1997

Language:

english

File:

PDF, 722 KB

english, 1997

8

Synthesis of a 5′-thiophosphate analogue of 2-5A, a phosphatase resistant activator of the 2-5A-dependent ribonuclease

Wei Xiao, Li Guiying, Krystyna Lesiak, Beihua Dong, Robert H. Silverman, Paul F. Torrences

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 445 KB

english, 1994

9

Bicyclic Monoterpene Diols Induce Differentiation of S91 Melanoma and PC 12 Pheochromocytoma Cells by a Cyclic Guanosine-Monophosphate-Dependent Pathway

DAVID A. BROWN, KRYSTYNA LESIAK, WU-YUN REN, KAREN L. STRZELECKI, ALEXANDER A. KHORLIN

Journal:

Pigment Cell & Melanoma Research

Year:

1999

Language:

english

File:

PDF, 1.24 MB

english, 1999

10

Conformational analysis of brominated pA2′-5′A2′-5′A analogs : An NMR and model-building study

Yvonne Th. van den HOOGEN, Coen M. A. HILGERSOM, Danuta BROZDA, Krystyna LESIAK, Paul F. TORRENCE, Cornelis ALTONA

Journal:

Year:

1989

Language:

english

File:

PDF, 808 KB

english, 1989

11

Phosphorylation of 2-5A core 5′-diphosphate to 2–5 a in mouse L cell extracts

Krystyna Lesiak, Paul F. Torrence

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 290 KB

english, 1985

12

Synthesis and biological activity of a fluorescent analogue of 2—5A

Krystyna Lesiak, Paul F. Torrence

Journal:

Year:

1983

Language:

english

File:

PDF, 480 KB

english, 1983

13

AIDS dementia: Synthesis and properties of a derivative of 3′-azido-3′-deoxythymidine (AZT) that may become ‘locked’ in the central nervous system

Paul F. Torrence, Jun-ei Kinjo, Krystyna Lesiak, Jan Balzarini, Erik De Clercq

Journal:

Year:

1988

Language:

english

File:

PDF, 602 KB

english, 1988

14

Inhibition of the RNA polymerase of vesicular stomatitis virus by ppp5′A2′p5′A and related compounds

Malathy Subramanian, Terez Kovacs, Krystyna Lesiak, Paul F. Torrence, John Lenard

Journal:

Antiviral Research

Year:

1990

Language:

english

File:

PDF, 509 KB

english, 1990

15

A new and potent 2-5A analogue which does not require a 5′-polyphosphate to activate mouse L-cell RNase L

Paul F. Torrence, Danuta Brozda, David K. Alster, Aysun Pabuccuoglu, Krystyna Lesiak

Journal:

Antiviral Research

Year:

1992

Language:

english

File:

PDF, 897 KB

english, 1992

16

Nuclear Magnetic Resonance Structure of d(GCATATGATAG)·d(CTATCATATGC): A Consensus Sequence for Promoters Recognized by σ K RNA Polymerase †,‡

Tonelli, Marco, Ragg, Enzio, Bianucci, Anna Maria, Lesiak, Krystyna, James, Thomas L.

Journal:

Year:

1998

File:

PDF, 54 KB

1998

17

Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analog, 3'-azido-dTTP

Kedar, Padmini S., Abbotts, John, Kovacs, Terez, Lesiak, Krystyna, Torrence, Paul, Wilson, Samuel H.

Journal:

Year:

1990

Language:

english

File:

PDF, 2.81 MB

english, 1990

18

Formation of α-Deoxyadenosine in Polydeoxynucleotides Exposed to Ionizing Radiation under Anoxic Conditions

Krystyna B. Lesiak and Kenneth T. Wheeler

Journal:

Radiation Research

Year:

1990

Language:

english

File:

PDF, 422 KB

english, 1990

19

Antibody-nucleic acid interactions. Monoclonal antibodies define different antigenic domains in 2',5'-oligoadenylates

Johnston, Margaret I., Imai, Jiro, Lesiak, Krystyna, Jacobsen, Helmut, Sawai, Hiroaki, Torrence, Paul F.

Journal:

Year:

1985

Language:

english

File:

PDF, 1.13 MB

english, 1985

20

Synthesis of Nonhydrolyzable Analogues of Thiazole-4-carboxamide and Benzamide Adenine Dinucleotide Containing Fluorine Atom at the C2‘ of Adenine Nucleoside: Induction of K562 Differentiation and Inosine Monophosphate Dehydrogenase Inhibitory Activity

Lesiak, Krystyna, Watanabe, Kyoichi A., Majumdar, Alokes, Seidman, Michael, Vanderveen, Kristen, Goldstein, Barry M., Pankiewicz, Krzysztof W.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 161 KB

english, 1997

21

Immunochemical analysis of the structure of 2',5'-oligoadenylate

Johnston, Margaret I., Imai, Jiro, Lesiak, Krystyna, Torrence, Paul F.

Journal:

Year:

1983

Language:

english

File:

PDF, 1.04 MB

english, 1983

22

Respective role of each of the purine N7 nitrogens of 5'-O-triphosphoadenylyl(2' .fwdarw. 5')adenylyl(2' .fwdarw. 5')adenosine in binding to and activation of the RNase L of mouse cells

Jamoulle, Jean Claude, Lesiak, Krystyna, Torrence, Paul F.

Journal:

Year:

1987

Language:

english

File:

PDF, 1.87 MB

english, 1987

23

Synthesis of a Methylenebis(phosphonate) Analogue of Mycophenolic Adenine Dinucleotide: A Glucuronidation-Resistant MAD Analogue of NAD

Lesiak, Krystyna, Watanabe, Kyoichi A., Majumdar, Alokes, Powell, James, Seidman, Michael, Vanderveen, Kristen, Goldstein, Barry M., Pankiewicz, Krzysztof W.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 114 KB

english, 1998

24

Structure-activity relationships for and potentiation of the antimitogenic activity of 2-5A core derived from 2-5A, a mediator of interferon action

Torrence, Paul F., Imai, Jiro, Lesiak, Krystyna, Warrinnier, Johan, Balzarini, Jan, De Clercq, Erik

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 624 KB

english, 1983

25

Efficient Synthesis of Methylenebis(phosphonate) Analogues of P 1 ,P 2 -Disubstituted Pyrophosphates of Biological Interest. A Novel Plausible Mechanism

Pankiewicz, Krzysztof W., Lesiak, Krystyna, Watanabe, Kyoichi A.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 319 KB

english, 1997

26

2',5'-Oligoadenylate:antisense chimeras. Synthesis and properties

Lesiak, Krystyna, Khamnei, Shahrzad, Torrence, Paul F.

Journal:

Bioconjugate Chemistry

Year:

1993

Language:

english

File:

PDF, 764 KB

english, 1993

27

Synthesis of 2′-Deoxynucleoside 5′-Methylenebis-(phosphonate)s Using 2-(4-Nitrophenyl)ethyl Methylenebis(phosphonate) as the Phosphonylating Agent.

Lesiak, Krystyna, Watanabe, Kyoichi A., Pankiewicz, Krzysztof W.

Journal:

Nucleosides and Nucleotides

Year:

1998

Language:

english

File:

PDF, 220 KB

english, 1998

28

A Pseudosquare Knot Structure of DNA in Solution †

Ulyanov, Nikolai B., Ivanov, Valery I., Minyat, Elvira E., Khomyakova, Elena B., Petrova, Maria V., Lesiak, Krystyna, James, Thomas L.

Journal:

Year:

1998

Language:

english

File:

PDF, 314 KB

english, 1998

29

Oligonucleotide structural parameters that influence binding of 5'-O-triphosphoadenylyl-(2' .fwdarw. 5')-adenylyl-(2' .fwdarw. 5')-adenosine to the 5'-O-triphosphoadenylyl-(2' .fwdarw. 5')-adenylyl-(2' .fwdarw. 5')-adenosine dependent endoribonuclease: chain length, phosphorylation state, and heterocyclic base

Torrence, Paul F., Imai, Jiro, Lesiak, Krystyna, Jamoulle, Jean Claude, Sawai, Hiroaki

Journal:

Journal of Medicinal Chemistry

Year:

1984

Language:

english

File:

PDF, 1.17 MB

english, 1984

30

Synthesis and biological activity of tubercidin analogs of ppp5'A2'p(5'A2'p)n5'A

Jamoulle, Jean Claude, Imai, Jiro, Lesiak, Krystyna, Torrence, Paul F.

Journal:

Year:

1984

Language:

english

File:

PDF, 2.22 MB

english, 1984

31

Novel Mycophenolic Adenine Bis(phosphonate) Analogues As Potential Differentiation Agents against Human Leukemia 1

Pankiewicz, Krzysztof W., Lesiak-Watanabe, Krystyna B., Watanabe, Kyoichi A., Patterson, Steven E., Jayaram, Hiremagalur N., Yalowitz, Joel A., Miller, Michael D., Seidman, Michael, Majumdar, Alokes,

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

32

2-(4-Nitrophenyl)ethyl Methylenebis(phosphonate): A Versatile Reagent for the Synthesis of Nucleoside 5‘-Methylenebis(phosphonate)s

Lesiak, Krystyna, Watanabe, Kyoichi A., George, Jay, Pankiewicz, Krzysztof W.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 66 KB

english, 1998

33

Stereospecific synthesis of cyclic adenosine 3',5'-(SP)-[18O]phosphate

Baraniak, Janina, Lesiak, Krystyna, Sochacki, Marek, Stec, Wojciech J.

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 293 KB

english, 1980

34

The Practical Synthesis of a Methylenebisphosphonate Analogue of Benzamide Adenine Dinucleotide: Inhibition of Human Inosine Monophosphate Dehydrogenase (Type I and II) 1

Pankiewicz, Krzysztof W., Lesiak, Krystyna, Zatorski, Andrzej, Goldstein, Barry M., Carr, Stephen F., Sochacki, Marek, Majumdar, Alokes, Seidman, Michael, Watanabe, Kyoichi A.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 205 KB

english, 1997

35

Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analog, 3'-azido-dTTP [Erratum to document cited in CA112(19):174722h]

Kedar, Padmini S., Abbotts, John, Kovacs, Terez, Lesiak, Krystyna, Torrence, Paul, Wilson, Samuel H.

Journal:

Year:

1990

Language:

english

File:

PDF, 86 KB

english, 1990

36

Synthesis and biological activities of oligo(8-bromoadenylates) as analogs of 5'-O-triphosphoadenylyl(2'.fwdarw.5')adenylyl(2'.fwdarw.5')adenosine

Lesiak, Krystyna, Torrance, Paul F.

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 1.90 MB

english, 1986

37

Replacement of the ribofuranose oxygen of 2-5A derivatives by methylene: synthesis of an aristeromycin analog of 2-5A core 5'-monophosphate (5'-O-phosphoryladenylyl)(2'.fwdarw.5')adenylyl(2'.fwdarw.5')adenosine 5'-monophosphate

Sawai, Hiroaki, Lesiak, Krystyna, Imai, Jiro, Torrence, Paul F.

Journal:

Journal of Medicinal Chemistry

Year:

1985

Language:

english

File:

PDF, 1.53 MB

english, 1985

38

Synthesis of Methylenebis(Phosphonate) Analogues of Nucleotide Coenzymes. A Novel Coupling Mechanism

Pankiewicz, Krzysztof W., Lesiak, Krystyna B., Watanabe, Kyoichi A.

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1999

Language:

english

File:

PDF, 160 KB

english, 1999

39

Stereospecific synthesis of adenosine 3?,5?-(S P)- and -(R P)-cyclic phosphorothioates (cAMPS)

Baraniak, Janina, Kinas, Ryszard W., Lesiak, Krystyna, Stec, Wojciech J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1979

Language:

english

File:

PDF, 217 KB

english, 1979

40

Targeting RNA for Degradation with a (2', 5')-Oligoadenylate Antisense Chimera

Torrence, Paul, Xiao, Wei, Li, Guiying, Khamnei, Shahrzad, Lesiak, Krystyna, Maran, Avudaiappan, Maitra, Ratan, Kumar, Aseem, Dong, Beihua, Williams, Bryan, Silverman, Robert

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

1995

Language:

english

File:

PDF, 262 KB

english, 1995

41

Novel Mycophenolic Adenine bis (Phosphonate)S as Potent Anticancer Agents and Inducers of Cells Differentiation

Pankiewicz, Krzysztof W., Lesiak-watanabe, Krystyna

Journal:

Nucleosides and Nucleotides

Year:

1999

Language:

english

File:

PDF, 316 KB

english, 1999

42

Synthesis and Characterization of Composite Nucleic Acids Containing 2‵,5‵-Oligoriboadenylate Linked to Antisense DNA

XIAO, WEI, PLAYER, MARK R., LI, GUIYING, ZHANG, WEITENG, LESIAK, KRYSTYNA, TORRENCE, PAUL F.

Journal:

Antisense and Nucleic Acid Drug Development

Year:

1996

Language:

english

File:

PDF, 3.41 MB

english, 1996

43

2′,5′-01igoadenylates Inhibit Relaxation of Supercoiled DNA by Calf Thymus DNA Topoisomerase I

CASTORA, FRANK J., ERICKSON, CATHERINE E., KOVÁCS, TERÉZ, LESIAK, KRYSTYNA, TORRENCE, PAUL F.

Journal:

Journal of Interferon Research

Year:

1991

Language:

english

File:

PDF, 1.89 MB

english, 1991

44

Synthesis Of Asymmetric S, S, S-Trialkyl Phosphorotrithioates

Lesiak, Krystyna, Stec, Wojciech J.

Journal:

Synthetic Communications

Year:

1977

Language:

english

File:

PDF, 230 KB

english, 1977

45

Structural Analysis of the Solution Conformation of Methyl 4- O -β- d -Glucopyranosyl-α- d -Glucopyranoside by Molecular Mechanics and ab Initio Calculation, Stochastic Dynamics Simulation, and NMR Spectroscopy

Hardy, Barry J., Gutierrez, Alberto, Lesiak, Krystyna, Seidl, Ed, Widmalm, Göran

Journal:

Journal of Physical Chemistry

Year:

1996

Language:

english

File:

PDF, 429 KB

english, 1996

46

The Chemistry of Nicotinamide Adenine Dinucleotide (NAD) Analogues Containing C-Nucleosides Related to Nicotinamide Riboside [1]

Pankiewicz, Krzysztof, Watanabe, Kyoichi, Lesiak-Watanabe, Krystyna, Goldstein, Barry, Jayaram, Hiremagalur

Journal:

Current Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 73 KB

english, 2002

47

A novel route to 1-aminoalkylphosphonic acid

Stec, Wojciech J., Lesiak, Krystyna.

Journal:

Journal of Organic Chemistry

Year:

1976

Language:

english

File:

PDF, 378 KB

english, 1976

48

Adducts of Mannose 6-Phosphate with 5-Iodo-2′-Deoxyuridine and 2-5A as Potential Antiviral Agents

Lesiak, Krystyna, Clercq, Erik De, Torrence, Paul F.

Journal:

Nucleosides and Nucleotides

Year:

1989

Language:

english

File:

PDF, 689 KB

english, 1989

49

A Solid-Phase Synthesis of 2',5'-Linked Oligoadenylates (2-5A)

Lesiak, Krystyna, Uznanski, Bogdan, Terrence, Paul

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

1989

Language:

english

File:

PDF, 257 KB

english, 1989

50

Targeting RNA for Degradation with a (2'-5')Oligoadenylate-Antisense Chimer

Paul F. Torrence, Ratan K. Maitra, Krystyna Lesiak, Shahrzad Khamnei, Aimin Zhou and Robert H. Silverman

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.33 MB

english, 1993